Testosterone Metabolism by Testicular Tissue
نویسندگان
چکیده
منابع مشابه
The metabolism of testosterone and related steroids by kidney tissue.
Previous work from this laboratory has demonstrated that at least three enzyme systems are involved in the catabolism of testosterone by liver tissue of various animals. One enzyme system, catalyzing the oxidation of the alcohol group on C-17 to a ketone, requires diphosphopyridine nucleotide (DPN) as a cofactor (1). A second appears to act preferentially on the A4-androstene-3, 17-dione so for...
متن کاملStudies on testosterone metabolism in subjects with testicular feminization syndrome.
The metabolism of radioactive testosterone simultaneously administered intravenously and either orally or percutaneously has been studied in seven patients with the syndrome of testicular feminization and compared with that of normal males and females. This investigation was carried out in order to determine the relative contribution to urinary 17-oxo and 17beta-hydroxy androstane steroids of l...
متن کاملStudies in steroid metabolism. I. Metabolism of testosterone by human prostatic tissue slices.
Samuels (1) in 1947 developed a method of studying the metabolism of testosterone by tissue slices and found that this steroid was utilized by livers of a variety of animal species (2). Samuels and coworkers presented convincing evidence that this reaction was caused by an oxidative enzyme. In 1950 Sweat, Samuels, and Lumry (3) actually isolated such an enzyme system from steer liver; this enzy...
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Glucocorticoids are well-known as mediators of the systemic stress response. Increased glucocorticoid release and synthesis in response to endogenous or exogenous stressors have been shown to impair testicular hormone production in a variety of species and therefore may affect fertility. However, the physiological involvement of glucocorticoid hormones in tissue maturation and differentiation d...
متن کاملMetabolism of Fatty Acids by Testicular
Previous studies revealed a significant decrease in the content of phospholipids and acyl-esters in spermatozoa during their passage through the epididymis (Scott, Voglmayr & Setchell, 1967). These results prompted us to investigate whether testicular and ejaculated spermatozoa could utilize fatty acids, which presumably become available to the spermatozoa as a result of phospholipid hydrolysis...
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ژورنال
عنوان ژورنال: Journal of Andrology
سال: 1983
ISSN: 0196-3635
DOI: 10.1002/j.1939-4640.1983.tb00724.x